Abstract
Introduction Frailty is a clinical state that predisposes to patients to clinical deterioration in response to minor stressor events. Frailty tends to be more prevalent in patients with chronic conditions such as Chronic Obstructive Pulmonary Disease (COPD). Therefore, we aim to investigate the influence of clinical frailty on mortality in COPD patients. Methods Data collection from electronic records for patients seen in Ysbyty Ystrad Fawr, Neville Hall Hospital, Grange University Hospital or Royal Gwent Hospital between 5-17th June 2024 was completed as part of patient input to the National Respiratory Audit Programme, focussing on patients who were admitted with an acute COPD exacerbation. The data collected were clinical frailty as measured by the Clinical Frailty Scale (CFS), smoking status, and the life status of patients at the time of data collection. This data was then exported to an excel spreadsheet, anonymised and simplified for statistical analysis using chi squared tests. Results Of the total 209 patients, 84 were male and 125 were female; the mean age was 72. 113 patients were ex-smokers, 71 were current smokers, 7 had never smoked and 18 were not recorded. 97 patients had a CFS of 5 or above, 112 had a CFS of 4 or below. 48% of ex-smokers were frail whereas 40% of current smokers were frail (p=0.478). 161 patients were alive at the time of data collection. 29% of those classed as frail had died since their admission whereas 17.6% of those classed as not frail had died following their admission (p=0.030). Of those alive, 41.2% were still smokers on admission. Of those dead, only 25.6% were still smokers on admission (p=0.055). Conclusion COPD patients who are frail tend to have higher rates of mortality compared to those who are not. Future studies exploring the relationship between smoking and frailty are needed.