Could too low blood pressure in old age increase mortality?

Professor Sven Streit, MD, MSc PhD, is a practicing general practitioner (GP) in a rural community (Konoflingen) and Assistant Professor of General Internal Medicine and Primary Care at the University of Bern. He is past-president of the Swiss Organisation of Young GPs (JHaS) and served as chair of the European Organisation of Young GPs (VdGM). He tweets @Sven_Streit. This blog was originally published on OUPblog.

With increasing age, blood pressure rises as a consequence of arterial stiffness, caused by the biological process of ageing and arteries becoming clogged with fatty substances, otherwise known as arteriosclerosis. Large hypertension trials showed that lowering blood pressure in people over 60 is beneficial and lowers the risk of heart attacks, stroke, and all-cause mortality, even in people over 80. Since arterial hypertension, high blood pressure in the arteries, is the most important preventable cause of cardiovascular disease, it seemed obvious for at least two decades to treat hypertension without restrictions even patients over 60.

However, when it comes to the growing population group of people over 80, this may no longer make sense in all, as many of these people tend to have long-term conditions, take a lot of medicines, and have increased frailty. In addition, patients with these characteristics are often included in trials and therefore evidence lacks generalizability. Furthermore, observational studies raise concerns about lowering blood pressure too much, since there are several cohort studies showing that people with lower blood pressure tend to face more problems with dementia and are actually more likely to die.

However, current international guidelines for treating high blood pressure still tells doctors to lower blood pressure to low values of even <130mmHg, in almost all patients from the age of 60 years, equivalent to normal blood pressure. The implication for systolic blood pressure to be lower than 130 mmHG is usually fine for the healthier elderly; however, it is very low for those who are frail. This has fuelled discussions about the benefits and harms of lowering blood pressure too much in older patients, especially when they are frail.

Since the appropriateness of lowering blood pressure remains controversial in the oldest-old, we followed patients drawn from the general population for five years to test whether low blood pressure in patients receiving antihypertensive medicine, leads to cognitive decline and increased mortality compared to patients with higher blood pressure.

Our findings show that, yes, people with low blood pressure who receive blood-pressure lowering therapy are more likely to suffer from cognitive decline and increased mortality than people with higher blood pressure especially when they are frail. For mental abilities, age seems to play an important role. At age 85 and older, low blood pressure is associated with worse cognitive function, whereas in studies with patients aged 60 and under there was an association of higher blood pressure and cognitive decline.

Doctors thinking about prescribing blood pressure lowering therapy in older patients should consider the specific patients and their therapeutic goals. In the light of these findings, a more individual approach instead of “one size fits all” seems most appropriate and is also more patient-centered. This is especially important for very old and frail patients not just to follow those guidelines, in which people over 80 or frailty have been less considered.

Read the Age and Ageing Paper: Lower blood pressure during antihypertensive treatment is associated with higher all-cause mortality and accelerated cognitive decline in the oldest-old. Data from the Leiden 85-plus Study